Ans. Simple diffusion moves substances down its concentration gradient without the involvement of any other molecule and energy expenditure whereas active transport helps in the transport of molecules against the concentration gradient assisted by other protein molecules and requiring energy expenditure by the cell. Q2. How is simple diffusion different from osmosis? Ans. Simple diffusion is the movement of particles from an area of their higher to lower concentration whereas osmosis involves the movement of water molecules from the region of low solute concentration to the region of high solute concentration.